mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
Huntington’s disease (HD) is an autosomal dominant disorder caused by a mutation in the gene encoding the huntingtin protein (HTT) resulting in expansion of the polyglutamine (polyQ) stretch on its amino-terminus [7, 18, 26, 68]. HD pathogenesis advances …